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Carbolith 150 mg /kg (n = 7) 1.8 ± 0.5 (n = 8) 1.7 ± 0.9 (n = 11) 0.97 14) 5.2 ± 1.6 (n = 17) 633 ± 973 (n = 16) 2.6 ± 1.9 (n = 18) 5.2 ± 0.9 (n = 17) 633 ± 871 (n = 23) 0.96 ± 1.2 (n = 27) 0.97 ± 0.6 (n = 24) 14 days 7 3 0.1 mg/kg (n = 5) 11.3 ± 2.2 (n = 9) 13.6 ± 4.7 (n = 16) 1.0 Is cefdinir generic for omnicef 12) 7.8 ± 6.7 (n = 17) 933 ± 564 (n = 16) 3.6 ± 14 (n = 6) 7.8 ± 3.2 (n = 7) 933 ± 817 (n = 4) 6.2 ± 2.8 (n = generic pharmacy net 4) 5.8 ± 7.2 (n = 4) 15 days 13 4 2 (mean of 6) 1.6 ± 0.8 (n = 5) 15.7 ± 4.3 (n = 12) 16.4 ± 2.7 (n = 15) 0.86 17) 2.1 ± 0.6 (n = 8) 2.1 ± 0.9 (n = 8) 2.6 ± 2.5 (n = 9) 3.5 ± 0.8 (n = 9) 9.7 ± 14.6 (n = 8) 6.1 ± 0.5 (n = 6) 10.6 ± 4.2 (n = 6) 0.6 ± 0.9 (n = 3) 2 (mean of 1–6) 0.0 ± 0.2 (n = 14) 0.0 ± 0.6 (n = 27) 0.1 15) 0.2 ± (n = 9) 0.1 0.5 17) ± 0.9 (n = 5) 0.0 ± 0.6 (n = 25) 0.7 ± 0.8 (n = 8) 13 days 15 4 2 View Large DISCUSSION This study is one of the first clinical trials to investigate the therapeutic efficacy of low-dose aspirin therapy in preventing and treating ischemic stroke in young men. We found that low-dose aspirin therapy in conjunction with conventional management of coronary artery disease, lipid-lowering medications, physical activity, or other preventive measures resulted in a significant reduction clinical stroke in men aged 18–30 years. Previous clinical trials with lower doses of aspirin have not been consistent; some trials showed an antiplatelet effect of modest magnitude [19], and this finding has been confirmed by several recent meta-analyses [20, 21]. Our findings indicate a more pronounced antiplatelet effect at higher doses in young men aged 18–30 years, with comparable or superior safety, and suggest that this effect could be further exacerbated by more intensively applied and longer-acting antiplatelet agents. The lack of effect in older men, which did not differ between groups, might be ascribed to differences in baseline risk of stroke. our current study, the average incidence of ischemic stroke was 13.1 days/100,000 person-years for young men and 6 days/100,000 person-years for elderly men. Therefore, the incidence rate in our older patients was significantly less, consistent with the findings of others [22]; however, these patients might have had a slightly older and more vulnerable state. Our lower rate among the elderly subjects may also be explained by the increased risk for stroke in this cohort, which aspirin treatment for 4–6 months prior to onset of symptoms was more commonly used before the end of trial (Table 2), as indicated by the fact that they were more frequently prescribed antiplatelet agents (n = 1) than older men (n = 10; table 1). Our findings were further supported by the fact that incidence of stroke decreased to 2.3 days/100,000 person-years in all men the aspirin-treatment and control group. To our knowledge, this is a novel study that included large number of subjects to investigate the long-term efficacy of low-dose aspirin therapy in preventing and managing ischemic stroke in young men. All patients had low baseline LDL-c. This finding can suggest that a combination of dietary counseling and regular physical activity improves lipid management in this population [23], suggesting that low-dose aspirin therapy for 5 weeks could be an effective intervention in this specific subpopulation.

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